Hong Kong · Sponsored
Comparison of the metabolic changes from the TANGO trial: a post-hoc analysis
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The introduction of combined antiretroviral therapy (cART) in the mid-1990s has improved the prognosis and survival of people living with human immunodeficiency virus (PWH). However, cART has been associated with weight gain and other adverse metabolic health outcomes, including hyperlipidaemia and insulin resistance, which could accelerate progression into type 2 diabetes mellitus or atherosclerotic cardiovascular disease. In particular, the newer class of ART called integrase strand transfer inhibitors (INSTIs) is associated with greater weight gain as compared to other HIV treatments such a
